When they compared cartilage from young and old mice, they found that levels of 15-PGDH approximately doubled with age. To test the idea, researchers treated older mice with a small molecule drug that blocks 15-PGDH activity. [And cartilage regrew.]
Sounds very promising! I couldn’t figure out the peer-reviewed-ness status.
Yeah but while PGE2 promotes cartilage repair, it also plays roles in inflammation, fever, and gastrointestinal issues. If PGE2 levels rise too high or in the wrong context, it could cause unwanted inflammation or side effects similar to NSAIDs (e.g. stomach irritation).
Sounds very promising! I couldn’t figure out the peer-reviewed-ness status.
Yeah but while PGE2 promotes cartilage repair, it also plays roles in inflammation, fever, and gastrointestinal issues. If PGE2 levels rise too high or in the wrong context, it could cause unwanted inflammation or side effects similar to NSAIDs (e.g. stomach irritation).
I think I’d be okay with some stomach irritation to regain use of my knees in my old age.
in mice though, since none of these recent one works in humans yet.