Yep, that’s leptin resistance for you. Obesity is really a hormonal condition, and this is why GLP-1 inhibitors are so effective - they actually treat the hormonal condition and allow the recipient to manage their food intake without having their body hormonally work against them.
A layman’s explanation (to be clear, I am the layman) of my best understanding of the subject:
Hunger is controlled by 2 hormones:
- Ghrelin, which causes hunger and is produced by the stomach
- Leptin, which suppresses hunger and is produced by fat cells
As fat cells accumulate, leptin levels also increase, but a person that has developed leptin resistance will not feel the appropriate amount of hunger suppression from the leptin, leading to chronic hunger unless large energy intake is sustained.
Yeah I think I have a normal appetite, my kids will laugh at me when I say I’m not hungry because I ate a big meal, they say “that was hours ago” but I stay full, or not hungry, my body wants to weigh more than I personally want it to (have BMI of 22) but doesn’t want to weigh more than it does now I guess.
So I understand when people say they used to be hungry and the drugs made them normal, it’s not a willpower thing, I don’t have to use willpower, just am not that hungry, naturally.
