We know it’s HEAVILY influence by genetics, but there seems to be some other component as well. That unknown piece, from what I understand, has not been discovered.
In identical twins (same DNA,) If one twin has ASD, the other only has it 96% of the time. If it was purely genetic, this should be 100%.
Not true, that’s called twin discordance. It’s very common. While they were born with the same DNA sequence, every person develops slightly differently and has a different epigenetic profile. The concept that twins are identical when developed was outdated about 20 years ago.
We know it’s HEAVILY influence by genetics, but there seems to be some other component as well. That unknown piece, from what I understand, has not been discovered.
In identical twins (same DNA,) If one twin has ASD, the other only has it 96% of the time. If it was purely genetic, this should be 100%.
https://www.nih.gov/news-events/news-releases/severity-autism-symptoms-varies-greatly-among-identical-twins
Not true, that’s called twin discordance. It’s very common. While they were born with the same DNA sequence, every person develops slightly differently and has a different epigenetic profile. The concept that twins are identical when developed was outdated about 20 years ago.
Isn’t twin discordance only referring to different weights/sizes at birth?
Could be down to gene drift or random mutation at that point, pretty sure that 4 percent is well within such variables.
Epigenetics (differences in gene expression) is more than sufficient; an actual mutation isn’t necessary.